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Proteus mirabilis

Taxonomy

Image of organism in genus Proteus mirabilis
Species:Proteus mirabilis
Genus:Proteus
Family:Morganellaceae
Order:Enterobacterales
Class:Gammaproteobacteria
Phylum:Proteobacteria

 

Disease Association:

Crohn's disease (ES=0.409461)

Type 2 diabetes (ES=0.748266)

Phenotypes

ShapeRod-shaped
Gram stainingGram-
MotilityMotile
Oxygen RequirementFacultative
SporulationNonsporulating
EcosystemHuman; Mammals
Ecosystem TypeExcretory system; Unclassified; Respiratory system; Circulatory system; Skin; Digestive system

Abundance overview

Healthy

Mean
Median
Industrialization
Alphabetical

Presence
Abundance
Without outliers
log Abundance


Disease

Mean
Median
Alphabetical

Presence
Abundance
Without outliers
log Abundance


Function overview

KEGG pathways

In the linked pathways:
red=enriched, blue=depleted

ko00010 - Glycolysis / Gluconeogenesis

ko00020 - Citrate cycle (TCA cycle)

ko00030 - Pentose phosphate pathway

ko00052 - Galactose metabolism

ko00061 - Fatty acid biosynthesis

ko00130 - Ubiquinone and other terpenoid-quinone biosynthesis

ko00230 - Purine metabolism

ko00240 - Pyrimidine metabolism

ko00250 - Alanine, aspartate and glutamate metabolism

ko00260 - Glycine, serine and threonine metabolism

ko00270 - Cysteine and methionine metabolism

ko00281 - Geraniol degradation

ko00290 - Valine, leucine and isoleucine biosynthesis

ko00300 - Lysine biosynthesis

ko00340 - Histidine metabolism

ko00400 - Phenylalanine, tyrosine and tryptophan biosynthesis

ko00430 - Taurine and hypotaurine metabolism

ko00450 - Selenocompound metabolism

ko00471 - D-Glutamine and D-glutamate metabolism

ko00473 - D-Alanine metabolism

ko00480 - Glutathione metabolism

ko00520 - Amino sugar and nucleotide sugar metabolism

ko00521 - Streptomycin biosynthesis

ko00540 - Lipopolysaccharide biosynthesis

ko00550 - Peptidoglycan biosynthesis

ko00564 - Glycerophospholipid metabolism

ko00620 - Pyruvate metabolism

ko00630 - Glyoxylate and dicarboxylate metabolism

ko00650 - Butanoate metabolism

ko00660 - C5-Branched dibasic acid metabolism

ko00670 - One carbon pool by folate

ko00710 - Carbon fixation in photosynthetic organisms

ko00720 - Carbon fixation pathways in prokaryotes

ko00730 - Thiamine metabolism

ko00740 - Riboflavin metabolism

ko00750 - Vitamin B6 metabolism

ko00760 - Nicotinate and nicotinamide metabolism

ko00770 - Pantothenate and CoA biosynthesis

ko00780 - Biotin metabolism

ko00785 - Lipoic acid metabolism

ko00790 - Folate biosynthesis

ko00791 - Atrazine degradation

ko00903 - Limonene and pinene degradation

ko00910 - Nitrogen metabolism

ko00920 - Sulfur metabolism

ko00970 - Aminoacyl-tRNA biosynthesis

ko00983 - Drug metabolism - other enzymes

ko01040 - Biosynthesis of unsaturated fatty acids

ko01110 - Biosynthesis of secondary metabolites

ko02010 - ABC transporters

ko02020 - Two-component system

ko02030 - Bacterial chemotaxis

ko02040 - Flagellar assembly

ko02060 - Phosphotransferase system (PTS)

ko03010 - Ribosome

ko03018 - RNA degradation

ko03030 - DNA replication

ko03060 - Protein export

ko03070 - Bacterial secretion system

ko03410 - Base excision repair

ko03430 - Mismatch repair

ko03440 - Homologous recombination

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KEGG modules

M00002 - Glycolysis, core module involving three-carbon compounds

M00003 - Gluconeogenesis, oxaloacetate => fructose-6P

M00004 - Pentose phosphate pathway (Pentose phosphate cycle)

M00005 - PRPP biosynthesis, ribose 5P => PRPP

M00006 - Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P

M00007 - Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P

M00008 - Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate

M00009 - Citrate cycle (TCA cycle, Krebs cycle)

M00010 - Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate

M00012 - Glyoxylate cycle

M00015 - Proline biosynthesis, glutamate => proline

M00016 - Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine

M00017 - Methionine biosynthesis, apartate => homoserine => methionine

M00018 - Threonine biosynthesis, aspartate => homoserine => threonine

M00019 - Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine

M00020 - Serine biosynthesis, glycerate-3P => serine

M00021 - Cysteine biosynthesis, serine => cysteine

M00022 - Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate

M00035 - Methionine degradation

M00048 - Inosine monophosphate biosynthesis, PRPP + glutamine => IMP

M00049 - Adenine ribonucleotide biosynthesis, IMP => ADP,ATP

M00050 - Guanine ribonucleotide biosynthesis IMP => GDP,GTP

M00051 - Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP

M00053 - Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP

M00060 - Lipopolysaccharide biosynthesis, KDO2-lipid A

M00063 - CMP-KDO biosynthesis

M00064 - ADP-L-glycero-D-manno-heptose biosynthesis

M00082 - Fatty acid biosynthesis, initiation

M00086 - beta-Oxidation, acyl-CoA synthesis

M00093 - Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE

M00096 - C5 isoprenoid biosynthesis, non-mevalonate pathway

M00116 - Menaquinone biosynthesis, chorismate => menaquinol

M00117 - Ubiquinone biosynthesis, prokaryotes, chorismate => ubiquinone

M00119 - Pantothenate biosynthesis, valine/L-aspartate => pantothenate

M00121 - Heme biosynthesis, glutamate => heme

M00123 - Biotin biosynthesis, pimeloyl-ACP/CoA => biotin

M00124 - Pyridoxal biosynthesis, erythrose-4P => pyridoxal-5P

M00127 - Thiamine biosynthesis, AIR => thiamine-P/thiamine-2P

M00134 - Polyamine biosynthesis, arginine => ornithine => putrescine

M00140 - C1-unit interconversion, prokaryotes

M00144 - NADH

M00149 - Succinate dehydrogenase, prokaryotes

M00150 - Fumarate reductase, prokaryotes

M00153 - Cytochrome bd ubiquinol oxidase

M00157 - F-type ATPase, prokaryotes and chloroplasts

M00165 - Reductive pentose phosphate cycle (Calvin cycle)

M00167 - Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P

M00176 - Assimilatory sulfate reduction, sulfate => H2S

M00308 - Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P

M00364 - C10-C20 isoprenoid biosynthesis, bacteria

M00365 - C10-C20 isoprenoid biosynthesis, archaea

M00417 - Cytochrome o ubiquinol oxidase

M00432 - Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate

M00525 - Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine

M00526 - Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine

M00527 - Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine

M00530 - Dissimilatory nitrate reduction, nitrate => ammonia

M00535 - Isoleucine biosynthesis, pyruvate => 2-oxobutanoate

M00542 - EHEC/EPEC pathogenicity signature, T3SS and effectors

M00554 - Nucleotide sugar biosynthesis, galactose => UDP-galactose

M00555 - Betaine biosynthesis, choline => betaine

M00570 - Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine

M00572 - Pimeloyl-ACP biosynthesis, BioC-BioH pathway, malonyl-ACP => pimeloyl-ACP

M00573 - Biotin biosynthesis, BioI pathway, long-chain-acyl-ACP => pimeloyl-ACP => biotin

M00577 - Biotin biosynthesis, BioW pathway, pimelate => pimeloyl-CoA => biotin

M00579 - Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate

M00632 - Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P

M00714 - Multidrug resistance, efflux pump QacA

M00718 - Multidrug resistance, efflux pump MexAB-OprM

M00761 - Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N

M00793 - dTDP-L-rhamnose biosynthesis

M00843 - L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4

M00844 - Arginine biosynthesis, ornithine => arginine

M00845 - Arginine biosynthesis, glutamate => acetylcitrulline => arginine

M00846 - Siroheme biosynthesis, glutamate => siroheme

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Antibiotic resistance

Undetected

Virulence factor class

Cell-to-cell spread

Cellular metabolism

Intracellular survival and replication

Invasion

Regulation of gene expression

Stress

Virulence

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Virulence factor gene

2-ketobutyrate formate-lyase (EC 2.3.1.-) @ Pyruvate formate-lyase (EC 2.3.1.54) (ID:Z4466)

Carbamoyl-phosphate synthase large chain (EC 6.3.5.5) (ID:Z0038)

Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) (ID:Z0037)

Chorismate synthase (EC 4.2.3.5) (ID:t0480)

Cytochrome O ubiquinol oxidase subunit I (EC 1.10.3.-) (ID:SL1344_0436)

D-sedoheptulose 7-phosphate isomerase (EC 5.3.1.28) (ID:SL1344_0306)

Dipeptide ABC transporter, substrate-binding protein DppA (TC 3.A.1.5.2) @ Dipeptide chemoreceptor (ID:c4361)

FKBP-type peptidyl-prolyl cis-trans isomerase SlyD (EC 5.2.1.8) (ID:STM474_3621)

GMP synthase [glutamine-hydrolyzing], amidotransferase subunit (EC 6.3.5.2) / GMP synthase [glutamine-hydrolyzing], ATP pyrophosphatase subunit (EC 6.3.5.2) (ID:S2725)

GTP-binding and nucleic acid-binding protein YchF (ID:c1661)

Holliday junction ATP-dependent DNA helicase RuvB (EC 3.6.4.12) (ID:SL1344_1828)

Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) / CBS domain (ID:STM2511)

Monothiol glutaredoxin GrxD (ID:E2348C_1740)

N,N'-diacetylchitobiose-specific 6-phospho-beta-glucosidase (EC 3.2.1.86) (ID:STM474_1321)

Phosphate transport system regulatory protein PhoU (ID:c4648)

PTS system, N,N'-diacetylchitobiose-specific IIB component (EC 2.7.1.196) (ID:SL1344_1247)

Pyruvate formate-lyase activating enzyme (EC 1.97.1.4) (ID:STM474_0956)

RNA polymerase-binding transcription factor DksA (ID:S0140)

Stringent starvation protein A (ID:STM14_4033)

Transketolase (EC 2.2.1.1) (ID:c3520)

Translation initiation factor SUI1-related protein (ID:SL1344_1638)

Trk potassium uptake system protein TrkA (ID:Z4660)

Tryptophan synthase beta chain (EC 4.2.1.20) (ID:Z2550)

Uncharacterized protease YegQ (ID:SL1344_2112)

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Secondary metabolite

Ladderane

Siderophore

Type-I polyketide synthetase (PKS)

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